No Time for Rest

No time to rest.

No REST for fibroids.

G ood news: A long-awaited model for uterine fibroid tumor research is upon us (1). Historically, there has been a paucity of in vivo models for the study of fibroid tumors (i.e., leiomyomas), benign female pelvic organ tumors characterized by clonal proliferation of smooth muscle cells and expression of genes involved in fibrosis and extracellular matrix (ECM) production. This is staggering, c...

No Rest for REST: REST/NRSF Regulation of Neurogenesis

Epigenetic strategies control the orderly acquisition and maintenance of neuronal traits. A complex network of transcriptional repressors and co-repressors mediates gene specificity for these strategies. In this issue of Cell, a study by Ballas and coworkers (Ballas et al., 2005) provides insight into the early lineage commitment events during neurogenesis. This study demonstrates that regulati...

Further good news on stroke, but no time for rest.

P rogressive reduction in stroke deaths over the last few decades has resulted in the recent preliminary announcement that stroke has declined from the third to the fourth-leading cause of death in the United States. 1 Moreover, the 2010 American Heart Association goal of reducing coronary heart disease and stroke mortality by 25% in the first decade of this century was achieved early, with a 3...

No rest for fatigue researchers.

F atigue is the most important side effect of cancer and cancer treatment, according to a recent study of patients and professionals in major cancer centers across the United States. Led by David Cella, Ph.D., at Evanston Northwestern Healthcare and Northwestern University's cancer center in Chicago, the study confirms not only that cancer-related fatigue is common but also that it affects pati...